Primary brain cancer - Acute
Rahul Soman, M. Pharm
Definition
Brain tumors are the compilation of intracranial neoplasms; each of these neoplasms is specific regarding biology, prognosis, and treatment ; primary brain tumors exclude metastatic or secondary malignant tumors.
Medical History
* Exposure to vinyl chloride
* Past medical history of Radiation therapy
* Past medical history of Epstein-Barr virus infection
* Past medical history of Solid organ transplant
* AIDS
* Past medical history of Simian adenovirus infection
* Hereditary disease
* Increased dietary intake of fat and cholesterol
* Dietary nitrate intake
Findings
* Headache
* Seizure
* Abducens nerve palsy
* Impaired cognition
* Aphasia
* Visual field defect
* Blurred vision
* Personality change
* Disturbance in mood
* Poor concentration
* Sensory agnosia
* Tactile agnosia
* Graphesthesia absent
* Absence of 2-point discrimination
* Alexia
* Auditory discrimination aphasia
* Inappropriate behavior
* Indifference
* Loss of judgement
* Amnesia
* Reduced concentration span
* Expressive language impairment
* Dysphasia
* Prosopagnosia
* Alexia
* Nystagmus
* Decreased level of consciousness - Acute
* Loss of consciousness
* Nausea and vomiting - Acute
* Loss of appetite
* Intracranial hemorrhage
* Hemiparesis
* Ataxia
* Spasticity
* Muscle weakness
* Dysmetria
* Intention tremor
* On examination - dysdiadochokinesia
* Respiratory depression
* Urinary retention
* Urinary incontinence
Tests
Suspected brain tumor and monitoring of known disease regarding extent, recurrence, and response to therapy
* Magnetic resonance imaging of brain and brain stem: A normal MRI with and without contrast rules out a brain tumor . MRI characteristics such as enhancement, edema, mass effect, and calcification determine specific tumor type .
Suspected or known primary CNS lymphoma in patients without increased intracranial pressure
* Cerebrospinal fluid examination: Molecular markers of monoclonality increase the yield for a positive diagnostic CSF analysis; malignant lymphoid cell are seen rarely , and a brain biopsy usually is required for a definitive diagnosis
Differential Diagnosis
* Cerebral metastases
* Infectious disease
* Inflammatory disorder
* Cerebrovascular disease
* Demyelinating disease of central nervous system
Treatment
Drug Therapy
Glioblastoma multiforme of brain
TEMOZOLOMIDE (Related toxicological information in TEMOZOLOMIDE)
Adults: concomitant to standard radiotherapy: initial dose, 75 mg/m2 orally daily for 42 days; cycle every 28 days beginning 4 weeks after completion of initial therapy
Adults: maintenance, cycle 1: 150 mg/m2 orally once daily for 5 days followed by 23 days without treatment; cycles 2-6 (each 28-days): 200 mg/m2 orally daily for the first 5 days of the cycle if common toxicity criteria (CTC) grade less than or equal to 2 (except for alopecia, nausea and vomiting), absolute neutrophil count (ANC) greater than or equal to 1.5 x 109/L, and the platelet count is greater than or equal to 100 x 109/L; The dose remains at 200 mg/m2 per day for the first 5 days of each subsequent cycle except if toxicity occurs; if the dose was not escalated at Cycle 2, escalation should not be done in subsequent cycles
Procedural Therapy
MRI compatible with or suggestive of primary brain tumor
* Surgical procedure
Primary brain cancer
* Radiation therapy procedure or service
I''m Charlotte Johnson,65 years old, Here in Edmonton, Canada. With the new herbal mix medicine I purchased from Dr James herbal mix medicine West Africa was my only way to get rid of my Alzheimer's, the herbal mix medicine effectively reversed my condition and alleviate all symptoms. I was initially very hesitant to discuss my Alzheimer but I just hope it can still help someone. I feel this will be very important information for all Alzheimer patients, because the most violent element in society today is ignorance. Be it any condition, a healthy diet and natural herbs and roots medicine from Dr. James is the road to fast recovery. I had suffered Alzheimer for many years, I fought for proper medical recommendation, care and all form of humane treatment with little improvement I went through many sleepless nights and periods of intense grief, as do most families. I was recommended by a friend to use Dr. James herbal mix medicine for my Alzheimer with high hope and assurance. I never doubted my friend but to contact Dr. James. And purchased His herbal mix medicine which was effective and I finally feel my Alzheimer is gone with no more symptoms. He also told me that he cures diseases such as Lungs diseases, kidney diseases, Warts, Bipolar disorder, Shingles, HPV, ALS, CANCER, NEPHROTIC SYNDROME, HIV / AIDS, Herpes virus, Ovarian Cancer, Pancreatic cancers, bladder cancer, prostate cancer, Glaucoma., Cataracts, Macular degeneration, Cardiovascular disease, Autism. Enlarged prostate, Osteoporosis. Alzheimer's disease, psoriasis, Tach Diseases, Lupus, Backache, dementia, skin cancer,.testicular Cancer, Leukemia, HEPATITIS A, B, C, Contact the great one on his email greatcureman@gmail.com
ReplyDeleteInfo @ drjamesherbalmix@gmail.com