Thursday, March 11, 2010

Viral encephalitis

Viral encephalitis - Acute

Definition  

An acute viral infection of the brain parenchyma causing an inflammatory process in association with clinical evidence of neurologic dysfunction


 

Medical History  

* Adult, Geriatric (>65 years)

* Pediatric (0-18 years)

* Neonate (<30 days and 37 weeks of gestation or more)

* Mosquito bite

* Tick bite

* Occupational Exposure

* Outdoor Recreational Activities

* Animal Contact

* Travel

* Past medical history of Inadequate immune status

* Infection after transfusion, Transfusion of blood product

* Patient immunocompromised and Immunodeficiency disorder

* Disorder related to transplantation, Transplantation


 

Findings  

* Fever

* Headache

* Altered mental status

* Nuchal rigidity

* Viral exanthem

* Lymphadenopathy - Acute

* Disturbance in speech

* Seizure

* Nausea and vomiting - Acute

* Myalgia

* Mosquito bite

* Pharyngeal erythema

* Respiratory finding

* Fatigue

* Diarrhea

* Muscle weakness

* Tick bite

* Focal neurological signs

* Impaired cognition

* Personality change

* Amnesia

* Abnormal movement

* Backache

* Dizziness

* Abdominal pain - Acute

* Splenomegaly

* Radicular pain

* Muscle rigidity

* Altered behavior

* Hallucinations

* Cranial nerve disorder

* Facial palsy

* Hemiparesis

* Hemiplegia

* Neurological muscular paralysis

* Pyramidal sign

* Retinitis

* Diplopia

* Photophobia

* Nystagmus

* Ophthalmoplegia

* Optic disc swelling

* Impairment level of vision

* Parotid swelling

* Sensorineural hearing loss

* Dysuria

* Urgent desire to urinate

* Urinary incontinence


 

Tests  

Evaluation for bacterial and fungal etiologies of encephalitis  

* Blood culture


 

Suspected viral encephalitis  

* MRI of head: MRI is a valuable procedure for the early detection of viral encephalitis and in some cases may help to differentiate specific etiologies .


 

Suspected viral encephalitis  

* Cerebrospinal fluid examination: Cerebrospinal fluid analysis in patients with viral encephalitis typically shows lymphocytic pleocytosis, normal or mildly elevated protein, normal glucose, and negative Gram staining .


 

Viral encephalitis  

* Polymerase chain reaction analysis, Cerebrospinal fluid


 

Suspected bacterial meningitis  

* Cerebrospinal fluid culture: Bacterial culture of the cerebrospinal fluid is critical in making the diagnosis of bacterial meningitis, identifying the causative organism, and selecting the appropriate antibiotic treatment regimen .


 

Suspected viral encephalitis  

* Electroencephalogram: EEG may show cerebral involvement early in the course of encephalitis and is important in detecting nonconvulsive seizures in patients with mental status changes .


 

Suspected herpes simplex encephalitis  

* Herpes simplex virus DNA assay: A positive polymerase chain reaction test for herpes simplex virus (HSV) in cerebrospinal fluid is generally diagnostic of HSV encephalitis .


 

Suspected herpes simplex encephalitis  

* Herpes simplex virus 1 AND 2 antibody assay: Tests of cerebrospinal fluid for herpes simplex virus (HSV) antibodies may be useful after a week of therapy for HSV encephalitis, but HSV polymerase chain reaction (PCR) is recommended for diagnosis .


 

Suspected and known herpes simplex encephalitis  

* Magnetic resonance imaging of brain and brain stem: A cranial MRI showing a hemorrhagic encephalitis affecting the temporal and inferior frontal lobes strongly suggests herpes simplex virus encephalitis .


 

Suspected or known herpes simplex encephalitis  

* Computerized axial tomography of brain: Although the brain CT may be normal early in the course of herpes simplex encephalitis, typical findings include lesions in one or both temporal lobes .


 

Suspected herpes simplex virus encephalitis  

* Electroencephalogram: An EEG done early in the course of herpes simplex encephalitis may reveal periodic lateralized epileptiform discharges localized to the temporal lobes .


 

Suspected arboviral encephalitis  

* Encephalitis viral serology test: A 4-fold or greater change in virus-specific antibody levels between acute and convalescent sera in the appropriate clinical setting is confirmatory for arboviral encephalitis .


 

Suspected or known West Nile virus disease, including encephalitis  

* West Nile virus antibody assay: A 4-fold or greater change in virus-specific serum antibody levels is confirmatory for West Nile virus infection .


 

Suspected viral encephalitis  

* Electromyography: Electromyography may show significant abnormalities in viral encephalitis .


 

Differential Diagnosis  

* Bacterial meningitis - Acute

* Bacterial encephalitis

* Viral meningitis - Acute

* Fungal infection of central nervous system

* Parasitic encephalitis

* Intracranial abscess

* Subdural hematoma - Acute

* Vascular disorder

* Encephalopathy

* Disseminated encephalomyelitis, acute

* Disease due to JC polyomavirus

* Rabies - Acute

* Encephalitis due to human herpes simplex virus - Acute

* West Nile encephalitis

* Enterovirus infection of the central nervous system

* Encephalitis due to Herpesviridae

* Arbovirus encephalitis

* Measles of the central nervous system

* Mumps encephalitis

* Rubella encephalitis

* Adenoviral encephalitis

* Encephalitis due to influenza


 

Treatment  


 

Drug Therapy  


 

All cases of suspected viral encephalitis while awaiting diagnostic lab results  


 

ACYCLOVIR

Adults: 10 mg/kg IV every 8 hours

Neonates: 20 mg/kg IV every 8 hours

Pediatrics: 10 mg/kg IV every 8 hours


 

Herpes simplex encephalitis  


 

ACYCLOVIR

Adults: 10 mg/kg IV every 8 hours for 14 to 21 days

Neonates: 20 mg/kg IV every 8 hours for 21 days

Pediatrics: 10 mg/kg IV every 8 hours for 14 to 21 days


 

Cytomegalovirus (CMV) encephalitis  


 

GANCICLOVIR SODIUM - FOSCARNET SODIUM  

Adults: Ganciclovir 5 mg/kg IV every 12 hours AND foscarnet [60 mg/kg IV every 8 hours OR foscarnet 90 mg/kg IV every 12 hours] for 3 weeks, followed by maintenance therapy


 

Varicella zoster virus (VZV) encephalitis  


 

ACYCLOVIR

Adults: 10 to 15 mg/kg IV every 8 hours for 10 to 14 days


 

Possible treatment option in immunocompromised patients with human herpesvirus 6  


 

GANCICLOVIR SODIUM - FOSCARNET SODIUM  

Adults: Ganciclovir 5 mg/kg IV every 12 hours AND foscarnet [60 mg/kg IV every 8 hours OR foscarnet 90 mg/kg IV every 12 hours]


 

Procedural Therapy  


 

Refractory cerebral edema or impending uncal herniation  

* Decompression of brain


 

Increased intracranial pressure  

* Introduction of intracranial pressure measuring device


 

Reportable infectious diseases  

* Infectious disease notification: In the United States, specific infectious diseases must be reported to the state or local public health department .

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